Purpura fulminans bụ ọrịa na-efe efe nke na-anọchite anya ụdị sepsis siri ike. Ọ na-eme ka ọbara gbasaa na necrosis anụ ahụ. Ọ na-abụkarị ọrịa meningococcal na-efe efe na-akpata ya na nsonaazụ ya na-egbu egbu ma ọ bụrụ na e meghị ya n'oge.

Ahụ ọkụ dị elu, nnukwu mmebi nke ọnọdụ izugbe, vomiting na mgbu afọ bụ ihe mgbaàmà mbụ na-enweghị atụ. Otu ebe ma ọ bụ karịa na-acha ọbara ọbara na-acha odo odo na-agbasa ngwa ngwa n'akpụkpọ ahụ, na-abụkarị n'akụkụ ụkwụ ala. Nke a bụ purpura, ọnya na-agba ọbara nke akpụkpọ ahụ. Nrụgide dị na akpụkpọ ahụ adịghị awụsa ọbara ahụ ma ghara ime ka ntụpọ ahụ kwụsị nwa oge, ihe ịrịba ama nke "mwepụ" nke ọbara n'ime anụ ahụ. Nke a bụ n'ihi na Purpura Fulminans na-akpata mgbasa nke intravascular coagulation (DIC), nke bụ nhazi nke obere mkpụkọ ga-akpaghasị usoro ọbara (a thrombosis), na-eduzi ya na dermis na-ebute ọbara ọgbụgba na necrosis nke anụ ahụ. Ọrịa na-efe efe nwere ike iso ya na ọnọdụ ịma jijiji ma ọ bụ ọgba aghara nke onye ahụ metụtara.

N'ọtụtụ n'ime ikpe, purpura fulminans na-ejikọta ya na ọrịa nje na-efe efe na nke siri ike. Neisseria na-ekwu (meningococcus) bụ ihe na-ebutekarị ọrịa na-efe efe, na-aza ihe dịka 75% nke ikpe. Ihe ize ndụ nke ịzụlite purpura fulminans na-apụta na 30% nke ọrịa meningococcal na-akpa ike (IIMs). (2) 1 ruo 2 ikpe nke IMD kwa 100 bi na-eme kwa afọ na France, yana ọnụ ọgụgụ ikpe na-egbu ihe ruru 000%. (10)

Ihe nje nje ndị ọzọ nwere ike bụrụ ọrụ maka mmepe purpura fulminans, dịka Streptococcus oyi baa (pneumococcus) ma ọ bụ Haemophilus influenzae (Pfeiffer's bacillus). Mgbe ụfọdụ ihe kpatara ya bụ ụkọ protein C ma ọ bụ S, nke na-ekere òkè na coagulation, n'ihi mmebi nke mkpụrụ ndụ ihe nketa ketara: ngbanwe nke PROS1 gene (3q11-q11.2) maka protein C na PROC gene (2q13-q14). maka protein C. Ekwesiri ighota na purpura fulgurans nwere ike ime site na oria di nro dika okuko okuko, n'ime ihe di oke egwu.

Purpura fulminans nwere ike imetụta afọ ọ bụla, mana ụmụ ọhụrụ na-erubeghị afọ 15 na ndị nọ n'afọ iri abụọ ruo 20 nọ n'ihe ize ndụ ka ukwuu. (1) Ndị mmadụ na ndị na-emekọ ihe na-akpachi anya kwesịrị ịnata ọgwụgwọ prophylactic iji gbochie ihe ize ndụ ọ bụla nke ọrịa.

Amụma amụma na-ejikọta ya na oge ewepụtara iji were ọrụ. Purpura fulminans n'ezie na-anọchite anya ọnọdụ ahụike nke oke ngwa ngwa nke chọrọ ọgwụgwọ ọgwụ nje ozugbo enwere ike, na-echeghị nkwenye nke nchoputa ma ghara idobe nsonaazụ mbụ nke omenala ọbara ma ọ bụ nyocha ọbara. Purpura nke nwere opekata mpe otu ntụpọ nwere dayameta karịa ma ọ bụ nhata milimita 3, kwesịrị ịkpalite njikere na ọgwụgwọ ozugbo. Usoro ọgwụgwọ ọgwụ nje kwesịrị ịdị mma maka ọrịa meningococcal ma mee ya n'ime intravenous ma ọ bụ, na-emeghị nke ahụ, na intramuscularly.