Ihe kpatara ya ugboro ugboro, hyperandrogenism na-ezo aka na oke mmepụta nke homonụ nwoke na nwanyị. A na-egosipụta nke a site n'aka karịa ma ọ bụ obere akara nke virilization.

N'ime ụmụ nwanyị, ovaries na adrenal glands na-emepụta testosterone, mana na obere ego. A na-ahụkarị ya n'etiti 0,3 na 3 nanomoles kwa liter nke ọbara, ma e jiri ya tụnyere 8,2 ruo 34,6 nmol / L n'ime mmadụ.

Anyị na-ekwu maka hyperandrogenism mgbe ọkwa nke hormone a dị elu karịa ụkpụrụ. Ihe ịrịba ama nke virilization nwere ike ịpụta: 

• hyperpilosité;
• ihe otutu;
• isi nkwọcha ;
• hypertrophy muscle, wdg.

Mmetụta abụghị naanị aesthetic. O nwekwara ike ịbụ nke uche na mmekọrịta mmadụ na ibe ya. Na mgbakwunye, oke mmepụta nke testosterone nwere ike ibute enweghị ọmụmụ na nsogbu metabolism.

Enwere ike ịkọwa ya site na ihe dị iche iche, nke a na-ahụkarị bụ ndị a.

Ovarian dystrophy

Nke a na-eduga na polycystic ovary syndrome (PCOS). Nke a na-emetụta ihe dịka otu onye n'ime ụmụ nwanyị 1. Ndị ọrịa na-achọpụta pathology ha n'oge uto, mgbe ha na-achọ maka nsogbu nke hyperpilosity na oke otutu, ma ọ bụ mgbe e mesịrị, mgbe ha na-eche ihu na-amụghị nwa. Nke a bụ n'ihi na oke testosterone nke ovaries na-emepụta na-akpaghasị mmepe nke mkpụrụ ndụ ovarian, bụ ndị na-adịghị etozuo oke ịhapụ akwa ha. A na-egosipụta nke a site na nsogbu nke usoro nsọ nwanyị, ma ọ bụ ọbụna site na enweghị oge (amenorrhea).

Ọrịa hyperplasia nke adrenal

Ọrịa mkpụrụ ndụ ihe nketa a na-adịghị ahụkebe na-eduga n'ịrụ ọrụ nke adrenal, gụnyere oke mmepụta nke homonụ nwoke na mmepụta nke cortisol, hormone nke na-ekere òkè dị ukwuu na metabolism nke carbohydrates, abụba na protein. N'okwu a, hyperandrogenism na-esonyere ike ọgwụgwụ, hypoglycemia na mbelata ọbara mgbali. Ọrịa nje a na-egosipụtakarị onwe ya site n'ọmụmụ, ma n'ọnọdụ ụfọdụ na-agafeghị oke ọ nwere ike ichere ruo mgbe ha tolitere iji kpughee onwe ya. 

Akpụ akpụ na adrenal gland

Ọ dị ụkọ, nwere ike ibute oke nzuzo nke homonụ nwoke, kamakwa cortisol. Hyperandrogenism na-esokwa hypercorticism, ma ọ bụ ọrịa Cushing, bụ isi iyi nke ọbara mgbali elu.

Akpụ ovarian na-ezobe homonụ nwoke

Ihe kpatara nke a na-adịkarị ụkọ.

Menopause

Ka mmepụta nke homonụ nwanyị na-ebelata nke ukwuu, homonụ nwoke nwere ohere ikwupụta onwe ya. Mgbe ụfọdụ, nke a na-eduga n'ịchịkọta iwu, yana ihe ịrịba ama dị ịrịba ama nke virilization. Naanị nyocha ụlọ ọgwụ jikọtara ya na ntule hormonal, yana usoro onrogens, nwere ike kwado nchoputa ahụ. Enwere ike inye iwu ultrasound nke ovaries ma ọ bụ gland adrenal iji dokwuo ihe kpatara ya.

Ihe ịrịba ama ụlọ ọgwụ na-egosi hyperandrogenism bụ ndị a:

• hirsutism : ntutu dị mkpa. Karịsịa, ntutu na-apụta n'akụkụ ahụ nke na-enwekarị ntutu isi na ụmụ nwanyị (ihu, ọkpụkpụ, afọ, azụ azụ, isi, n'ime apata ụkwụ), nke nwere ike inwe mmetụta dị ukwuu nke uche na nke ọha mmadụ. ;
• ihe otutu et seborrhea (akpụkpọ anụ mmanu mmanu); 
• alopecia ụdị isi nkwọcha nwoke, na-enwekwu ntutu isi n'elu isi ma ọ bụ n'ihu globes.

Enwere ike jikọta akara ngosi ndị a na:

• nsogbu okirikiri ịhụ nsọ, na ma ọ bụ enweghị oge (amenorrhea), ma ọ bụ ogologo oge na usoro oge (spaniomenorrhea);
• clitoral gbasaa clitoromegaly na ịba ụba libido;
• ihe ịrịba ama ndị ọzọ nke virilization : olu nwere ike ịdị njọ karị na musculature na-echeta morphology nwoke.

Mgbe akara ya nke ukwuu, hyperandrogenism nwere ike ibute nsogbu ndị ọzọ na-adịte aka:

• nsogbu metabolic : oke mmepụta nke homonụ nwoke na-akwalite ibu ibu na mmepe nke nguzogide insulin, ya mere ihe ize ndụ nke oke ibu, ọrịa shuga na ọrịa obi;
• nsogbu gynecological, gụnyere nnukwu ihe ize ndụ nke ọrịa cancer endometrial.

Nke a bụ ya mere hyperandrogenism na-ekwesịghị ịtụle naanị site na echiche ịchọ mma. Ọ nwere ike ịchọ nlekọta ahụike.

Nlekọta na-adabere na mbụ na ihe kpatara ya.

N'ihe gbasara etuto

Achọrọ ịwa ahụ iji wepụ ya.

Maka ọrịa polycystic ovary

Enweghị ọgwụgwọ iji gbochie ma ọ bụ gwọọ ọrịa a, naanị ọgwụgwọ maka mgbaàmà ya.

• Ọ bụrụ na onye ọrịa anaghị eme ma ọ bụ karịa ụmụaka, ọgwụgwọ ahụ gụnyere itinye ovaries izu ike, iji belata mmepụta nke homonụ nwoke. A na-enye ọgwụ estrogen-progestin. Ọ bụrụ na nke a ezughi oke, enwere ike ịnye ọgwụ mgbochi androgen dị ka mgbakwunye, cyproterone acetate (Androcur®). Otú ọ dị, ebe ọ bụ na ejikọtala ngwaahịa a n'oge na-adịbeghị anya na ihe ize ndụ nke meningioma, a na-amachibido iji ya mee ihe na ikpe kachasị njọ, nke uru / ihe ize ndụ dị mma;
• N'ihe banyere ọchịchọ ime ime na infertility, a na-atụ aro mkpali dị mfe nke ovulation site na akara mbụ clomiphene citrate. A na-eme nyocha amụghị nwa iji chọpụta na enweghị ihe ndị ọzọ metụtara. Ọ bụrụ na mkpali ọgwụ ọjọọ anaghị arụ ọrụ, ma ọ bụ ọ bụrụ na achọpụtara ihe ndị ọzọ na-akpata ịmụ nwa, a na-atụle intrauterine insemination ma ọ bụ in vitro fertilization. 

Enwere ike ịnye iwepụ ntutu isi laser iji belata uto ntutu na ọgwụgwọ anụ ahụ mpaghara megide ihe otutu.

N'ọnọdụ ọ bụla, a na-atụ aro ịme egwuregwu na ịgbaso nri kwesịrị ekwesị. N'ihe banyere oke ibu, mfu nke ihe dịka 10% nke ibu mbụ na-ebelata hyperandrogenism na nsogbu ya niile. 

N'ọnọdụ nke hyperplasia adrenal

Mgbe ọrịa ahụ sitere na mkpụrụ ndụ ihe nketa, a na-etinye nlekọta pụrụ iche na ebe ndị ọkachamara n'ọrịa ndị na-adịghị ahụkebe. Ọgwụgwọ gụnyere corticosteroids karịsịa.