Ịrụ ọrụ endothelial na-ekere òkè dị ukwuu na mmalite nke ọrịa na karịsịa ọrịa obi. Kedu ka esi akọwa endothelium, gịnị bụ ọrụ ya? Kedu ihe ndị dị ize ndụ na-eduga n'ịrụ ọrụ endothelial?

Endothelium vaskụla na-etolite ihe mgbochi cellular n'etiti anụ ahụ na ọbara. Ọ bụ isi ihe na-achịkwa vasomotor phenomena nke vaskụla permeability, ụda na nhazi nke arịa. Selụ endothelial, na nzaghachi nye mkpali, na-emepụta ụmụ irighiri ihe na-achịkwa.

Iji belata ihe ize ndụ nke obi, endothelium bụ akụkụ mgbochi na ọgwụgwọ kachasị mkpa.

N'okpuru mmetụta nke ịka nká na ihe ize ndụ vaskụla, enwere ike ịmegharị endothelium ma mee mgbanwe ọrụ nke nwere ike igbochi ọrụ a, onye ahụ na-ekwukwa banyere "nkwụsị ọrụ endothelial".

A na-akọwa dysfunction endothelial dị ka ihe na-adịghị mma na endothelial na-adabere na vasodilation nke kpatara site na mbelata ihe ndị na-akpata vasodilator, dị ka nitric oxide (NO), na-akawanye njọ endothelial activation. Nke a na-arụ ọrụ na-eme ka ntọhapụ nke adhesion ụmụ irighiri ihe site na endothelium na macrophages (sel ndị dị na ọbara ọcha, nke na-abanye n'ime anụ ahụ. N'oge thrombosis na mbufụt, ụmụ irighiri ihe ndị a na-etinye aka na ntinye nke leukocytes na l platelet adhesion.

Enwere ihe ize ndụ ọdịnala na nke na-abụghị nke ọdịnala.

Ihe ize ndụ ọdịnala

N'ime ihe ndị omenala, a na-ahụ nkwụsị nke endothelial na ndị ọrịa nwere ihe ize ndụ nke obi, dyslipidemia, ọrịa shuga, ọbara mgbali elu. ụtaba, afọ, na ihe nketa bụkwa ihe ndị a ga-atụle.

Ihe ize ndụ na-abụghị omenala

N'ime ihe ndị a na-akpọ ihe ndị na-abụghị omenala, enwere enweghị aha na mmepụta nke vasodilator ma ọ bụ ihe ndị na-akpata vasoconstrictor nke na-eduga ná mgbanwe na ikike vasodilator nke endothelium, bụ isi ihe na-egosi nkwụsị ọrụ nke endothelial.

Ọrụ endothelial, n'ihi mmetụta vasculoprotective nke nitric oxide (NO), na-echebe ahụike obi.

Ngwọta endothelial bụ ihe na-ekwupụta mmalite nke ọrịa ụfọdụ:

• Ihe omume obi;
• Nguzogide insulin;
• Hyperglycemia;
• Ọbara mgbali elu;
• Dyslipidémie.

Ọgwụ ndị na-enye aka gụnyere statins, bụ́ ndị na-ebelata cholesterol ọ bụrụgodị na ọkwa cholesterol bụ ihe nkịtị ma ọ bụ na-ebuli elu dịtụ elu, na mgbe ụfọdụ aspirin ma ọ bụ ọgwụ ndị ọzọ na-egbochi platelet, ọgwụ ndị na-egbochi platelet ịgbakọta ọnụ na ịmalite mgbochi n'ime arịa ọbara.

Ụfọdụ ọgwụ ndị a na-eji agwọ ọbara mgbali elu na ụfọdụ ọgwụ ndị a na-eji agwọ ọrịa shuga na-ebelatakwa ihe ize ndụ ahụ.

Ụzọ nke ịchọpụta dysfunction endothelial, mmekpa ahụ ma ọ bụ nke na-adịghị emerụ ahụ, arụ ọrụ ma ọ bụ ndu, bụ ụzọ ozi nke na-eme ka ihe ọmụma nke pathophysiology nke obi na-eme ka ọ dịkwuo mma na nke na-enye ohere, ruo n'ókè ụfọdụ, iji nyochaa irè ọgwụgwọ ọgwụgwọ. na prognosis nke ụfọdụ ìgwè ndị ọrịa.

N'ime ụmụ mmadụ, enwere ike ime atụmatụ nrụrụ endothelial site n'ịtụ:

• Ngwunye Plasma nke metabolites nke dinitrogen monoxide (NO): ngwaahịa na-akwụsighị ike, enweghị ike ikpebi n'ime ọbara, n'aka nke ọzọ, mkpebi nke metabolites ya (nitrates na nitrates) ga-ekwe omume na mmamịrị;
• Ngwunye Plasma nke ụmụ irighiri ihe nkedo: ụmụ irighiri ihe ndị a na-ekere òkè na usoro mkpali site n'ikwe ka adhesion nke monocytes na endothelium, mgbe ahụ, ịkwaga ha n'ime mgbidi nke akwara na veins;
• Ihe nrịbama akara.

Ọtụtụ akara nrịbama ndu na-agbakwa ama maka arụrụ arụ nke endothelial. Protein C-reactive nke ukwuu (CRP) na extracellular superoxide dismutase (usoro enzyme siri ike) so na ha.

Iji gbochie nrụrụ nke endothelial, a tụpụtara ọtụtụ atụmatụ gụnyere nri. A na-akọwapụta ọrụ nke ihe mejupụtara nri dị ka fatty acids, vitamin antioxidant, folate, vitamin D na polyphenols.

• Ọkwa vitamin D dị ala na-eduga n'ihe ize ndụ dị ukwuu nke ọrịa obi na ọrịa shuga 2;
• Nchegbu oxidative nwere ike imetụta ọrụ endothelial site na mbufụt ma belata ONWEGHỊ nnweta;
• Lycopene, antioxidant dị ike, ga-ebelata ihe nrịbama maka ịgbalite endothelium, protein reactive C, na ọbara mgbali systolic ma nwee mmetụta bara uru na nrụgide oxidative;
• Polyphenols na-enye tumadi site na mkpụrụ osisi, akwụkwọ nri, koko, tii na mmanya uhie. Ejikọtara oriri ha na obere ihe ize ndụ nke ọrịa obi.