Akọwapụtara site na ọnụnọ nke oke acidity dị n'ọbara, acidosis bụ nsonaazụ nke ọrịa metabolic dị iche iche na ọrịa nke na-emepụta oke acidity. Mgbe ụfọdụ, ọ bụ ihe mberede dị mkpa. Nlekọta ya dabere na ịgwọ ihe kpatara ya. 

Ọnụnọ nke metabolic acidosis n'ime ahụ jikọtara ya na mmụba nke mmepụta ma ọ bụ iri acid na / ma ọ bụ mbelata nke mkpochapụ nke acid. Ọ bụkwa mgbe ụfọdụ ihe kpatara mfu site na tract digestive ma ọ bụ akụrụ nke bicarbonates (HCO3-) nke na-echekwa oke ọnụnọ acid n'ime ọbara ma soro na nguzozi acid-base.

Dị ka ọ na-adịkarị, plasma (akụkụ ọbara na-enweghị mkpụrụ ndụ ọbara uhie, mkpụrụ ndụ ọbara ọcha na platelet) bụ mmiri na-anọpụ iche nke ọkụ eletrik, ya bụ, ọ nwere ọtụtụ ebubo ionic na-adịghị mma dị ka nke ziri ezi (HCOE-, H +, Na +, K +, CL-…). Ọ bụ mgbe ụgwọ dị mma dị ukwuu na ọnụ ọgụgụ nke metabolic acidosis na-apụta.

Enwere ọtụtụ ihe kpatara metabolic acidosis. Metabolic acidosis abụghị ọrịa n'onwe ya, mana okwu ndu nke enweghị ahaghị nhata n'ọbara n'etiti acidity na bicarbonates. Enweghị ahaghị nhata a bụ n'ihi ọtụtụ nsogbu enwere ike.

Ọnụnọ nke lactic acid dị ukwuu site na mkpokọta n'ime ọbara

Nke a organic acidosis bụ n'ihi: 

• ọnọdụ nke ujo physiological; 
• imeju imeju (imeju anaghịzi arụ ọrụ ya iji hichaa ọbara);
• ọrịa ọbara dị ka nnukwu leukemia ma ọ bụ lymphoma (cancer nke lymph nodes);
• ọrịa akụrụ na-adịghị ala ala (akụrụ anaghị ewepụ oke acid n'ọbara); 
• nri nsị (methanol, salicylates, ethylene glycol, wdg);
• ketoacidosis (ọrịa shuga mgbe insulin na-agwụ).

Ọnụnọ nke lactic acid dị ukwuu n'ọbara site na ibelata mkpochapụ ya

Nke a mineral metabolic acidosis sitere na:

• nnukwu ọdịda gbasara akụrụ;
• ngafe nke NaCl chloride infusion (nnu);
• mfu nke bicarbonate sitere na akụrụ;
• ọnwụ nke bicarbonate sitere na tract digestive (afọ ọsịsa);
• adrenal insufficiency.

Metabolic acidosis nwekwara ike ime na nnukwu iku ume iku ume nke ahụ enweghị ike iwepụ carbon dioxide site na ngụgụ, nke na-ebute acidification nke plasma ọbara. A na-akpọkwa acidosis ahụ "ihe iku ume".

Mgbe nguzozi acid-base nke ahụ na-ewe iwe n'agbanyeghị ihe kpatara ya, enwere ike igosipụta mgbaàmà dị iche iche. Ọ bụrụ na enweghị ahaghị nhata a, a gaghị enwe akara ngosi ma ewezuga ihe kpatara ya (afọ ọsịsa, ahụ erughị ala jikọtara ya na ọrịa shuga na-enweghị isi, wdg). Ma ahaghị nhata na-emesi ike (pH <7,10), mgbaàmà ndị a nwere ike ime:

• nhazi;
• agbọ agbọ;
• ahụ adịghị mma;
• ụbara ume iku ume (polypnea na mbọ iji kpochapụ oke acidity metabolic);
• ọbara mgbali elu dị ala (hypotension) ma ọ bụ ọbụna ujo obi na obi arrhythmias na coma.

Mgbe acidosis a dị n'ụzọ na-adịghị ala ala (okpukpu iku ume na-adịghị ala ala…), ọ nwere ike ime ka n'oge na-adịghị anya mfu nke calcium site na ọkpụkpụ (osteoporosis, rickets).

E wezụga ịchọ ihe kpatara ya site na nyocha ndị mmekọ, nyocha ọbara n'ogo nke akwara na-atụle gas ọbara na serum electrolytes ga-eme ka ọ pụta ìhè nsonaazụ ndụ nke metabolic acidosis.

Akụkọ ahụike ga-enyo enyo ihe kpatara ọrịa metabolic acidosis (ọrịa shuga, iku ume, akụrụ ma ọ bụ ịba ọcha n'anya…) kamakwa site na nyocha nke ndu na-enyocha ọkwa shuga dị n'ọbara, ọrụ imeju na akụrụ, sodium na chlorine ọbara, ma ọ bụ ngwaahịa na-egbu egbu. ọbara (methanol, salicylate, ethylene glycol).

Ọgwụgwọ nke metabolic acidosis bụ nke mbụ na-akpata ya (ọrịa shuga na-enweghị oke, afọ ọsịsa, imeju, akụrụ ma ọ bụ iku ume, wdg). Ma na mberede mgbe metabolic acidosis siri ike, ọ na-adị mkpa mgbe ụfọdụ ịme ntinye nke sodium bicarbonate iji belata acidity nke plasma ọbara.

N'ọnọdụ nke ọdịda akụrụ siri ike ma ọ bụ nsị, hemodialysis (nyocha nke toxins si n'ọbara) ga-ehichapụ ọbara ma dochie ọrụ akụrụ.

N'ikpeazụ, n'ihu acidosis na-adịghị ala ala, a na-atụ aro nri iji weghachite nguzozi acid-base nke ọbara na ọtụtụ ndụmọdụ:

• họrọ nri alkaline na-abụkarị (ọgwụgwọ lemon, tii ginger, ugu osisi, wdg);
• nweta ikuku oxygen site na ịme egwuregwu mgbe niile n'èzí;
• were ihe mgbakwunye nri na-akwalite alkalization nke ọbara.