Uricemia bụ mmụba nke uric acid n'ime ọbara. Uric acid a na-esite na nbibi nke ngwaahịa nitrogen, na-eso catabolism nke acid nucleic nke dị na ahụ (DNA na RNA), ma ọ bụ mbibi nke purines na-abanye na nri. A na-ekpochapụ uric acid site na mmamịrị. Mmụba nke uric acid, nke a na-akpọ hyperuricemia, nwere ike ịkpata gout ma ọ bụ urolithiasis. A na-ahụ hypo-uricemia mgbe ụfọdụ mgbe ọgwụgwọ ụfọdụ gasịrị. Ịnabata àgwà iri nri nke ọma na-enyere aka ịnọgide na-enwe uricemia ziri ezi.

Uricemia bụ ọkwa nke uric acid na plasma ọbara. Uric acid a bụ ngwaahịa sitere na nbibi nke ngwaahịa nitrogen: yabụ, ọ na-esite na catabolism nke acid nucleic dị n'ime ahụ n'ụdị DNA na RNA, ma ọ bụ mebie site na mmebi nke purines na-abanye n'oge nri. Ya mere, uric acid bụ ihe mkpofu nke ahụ na-emepụta, karịsịa mgbe, n'oge ọnwụ na cell ọhụrụ, ọ na-eweda DNA na RNA ụmụ irighiri ihe (ụmụ irighiri ihe ndị na-ebu ozi mkpụrụ ndụ ihe nketa nke onye ahụ ma kwe ka nsụgharị ya ghọọ protein).

A na-achọta Uric acid n'ime ọbara, ebe a na-ekesa ya n'etiti plasma na mkpụrụ ndụ ọbara, na n'anụ ahụ. Uric acid enweghị ike gbanwee, dị ka nnụnụ, na allantoin: n'ezie, ụmụ mmadụ enweghị enzyme nke nwere ike imebi uric acid site na ụzọ a nke allantoin. Ya mere, uric acid a ga-esi na mmamịrị pụta n'ime mmadụ.

• Ọ bụrụ na ọdịnaya uric acid dị n'ọbara dị elu, ọ nwere ike ịgbakọta na nkwonkwo ma mee ka mbufụt na-ebute ọgụ gout, nke na-egbu mgbu.
• Ọ bụrụ na ọ na-anakọta na urinary tract, ọ nwere ike ime ka urolithiasis, na site na ọnụnọ nke nkume, na-akpatakwa nnukwu mgbu.

Ekwesịrị ime uricemia ma ọ bụrụ na dọkịta na-enyo enyo mmụba nke uric acid n'ime ọbara. Ya mere, a ga-eme nyocha nke ndu nke ọma:

• ma ọ bụrụ na onye dọkịta na-enyo enyo na ọ bụ ihe omume nke gout, mgbe onye ọrịa nwere mgbu nkwonkwo;
• maka nyochaa ụfọdụ ọrịa ebe hyperuricemia dị, dịka ọdịda akụrụ ma ọ bụ ọrịa ọbara ụfọdụ; 
• na-eso ịṅụ ọgwụ ụfọdụ dị ka diuretics nke na-egbochi mkpochapụ nke uric acid. 
• n'ihe banyere iribiga ihe ókè, nke nwekwara ike ime ka mmụba nke uric acid dị elu; 
• iji nyochaa hypo-uricemia;
• n'oge ime ime, ịchọpụta hyperuricemia nwere ike ime;
• n'ime ndị mmadụ nwere nkume akụrụ nke uric acid ma ọ bụ urate;
• maka nlekota nke isiokwu ndị na-egosilarị uricemia dị elu, iji chọpụta ihe ize ndụ nke nsogbu gbasara akụrụ.

A ga-ejikọta ule uric acid a na nyocha nke ọrụ akụrụ, site na ịlele ọkwa nke creatinine n'ime ọbara.

A na-eme mkpebi siri ike nke uric acid site na usoro enzymatic, na serum, na-eso ule ọbara. A na-ewere ihe nlele ọbara a n'aka onye na-ebu ọnụ, ma pụọ ​​​​na nri mmiri. A na-emekarị venipuncture na mpịachi nke ikpere ụkwụ. A na-eme ya na ụlọ nyocha ahụike, na-emekarị n'ime obodo, na-agbaso ndenye ọgwụ. Na nkezi, nsonaazụ dị n'ime awa 24 nke mkpokọta.

Uric acid na-ekesa n'ime ọbara na ọkwa nkịtị n'ime ụmụ nwanyị n'etiti 150 na 360 μmol kwa lita, na ụmụ nwoke n'etiti 180 na 420 μmol kwa lita. Ọkwa nkịtị na ndị okenye, na mg kwa liter, a na-ewerekarị dị n'etiti 25 ruo 60 n'ime ụmụ nwanyị yana 35 ruo 70 n'ime ụmụ nwoke. N'ime ụmụaka, ọ kwesịrị ịdị n'etiti 20 na 50 mg kwa lita (ya bụ 120 ruo 300 µmol kwa liter).

N'ihe banyere hyperuricemia, ya mere na uric acid itinye uche karịa 360 μmol / liter na ụmụ nwanyị na karịa 420 μmol / lita na ụmụ nwoke, onye ọrịa nọ n'ihe ize ndụ nke gout ma ọ bụ urolithiasis.

• Gout bụ ọrịa nkwonkwo metabolic, nke na-emetụtakarị nnukwu mkpịsị ụkwụ, ma mgbe ụfọdụ ọ na-emetụtakwa nkwonkwo ụkwụ na ikpere. Ọ na-akpata ya site na mmụba nke ọdịnaya uric acid n'ime ọbara na-eduga n'ịgbakọba na nkwonkwo mpụta nke kristal urate, na mbufụt. Ọgwụgwọ nke nnukwu ọgụ na-adaberekarị na colchicine. Enwere ike ịlụso hyperuricemia ọgụ site n'iwepụ ihe ọ bụla nwere ike ịkpata hyperuricemia, yana site na xanthine oxidase inhibitors (enzyme a na-agbanwe mkpụrụ ndụ a na-akpọ xanthine n'ime uric acid).

   

• Urolithiasis bụ ọnụnọ nke nkume n'ụzọ nke mmamịrị excretion, nke na-eme ka e guzobe kristal.

Hypo-uricemia, ntụgharị uche uric acid nke na-erughị 150 μmol / liter n'ime ụmụ nwanyị yana 180 μmol / liter n'ime ụmụ nwoke, bụ nke a na-ahụkarị n'oge ọgwụgwọ urico-ewepu ma ọ bụ urico-braking.

N'oge ochie, a na-akọ akụkọ banyere gout n'ihi iribiga ihe ókè na ịṅụbiga mmanya ókè. Mana ọ bụ naanị n'ime afọ iri gara aga ka nghọta sara mbara banyere ihe nri nri metụtara hyperuricemia na gout bịara pụta ìhè. Ya mere, ọtụtụ mgbe, ịri nri na-enye aka na mmụba nke uric acidemia nke usoro 10 mg / ml. Karịsịa, na ndị okenye nwere uricemia n'etiti 60 na 70 mg / ml, mmụba dị otú ahụ nwere ike ikpughe na gout.

Oke ibu, oke anụ uhie na nri na ihe ọṅụṅụ na-aba n'anya ka amatala dị ka ihe na-akpalite gout, kemgbe oge ochie. N'aka nke ọzọ, akwụkwọ nri na osisi ndị bara ụba na purines adịghị etinye aka, dịka ọtụtụ nchọpụta gosiri. N'aka nke ọzọ, a chọpụtala ihe ọhụrụ dị ize ndụ, bụ ndị a na-amatabeghị, gụnyere fructose na ihe ọṅụṅụ na-esi ísì ụtọ. N'ikpeazụ, a kọwokwa ihe nchebe, karịsịa oriri nke ngwaahịa mmiri ara ehi na-adịghị mma.

A na-eji Gout mara ọ bụghị naanị site na ụbara uric acid, ọrịa ogbu na nkwonkwo nwere ike ime na mmebi na-adịghị ala ala, mana enwere ike jikọta ya na nnukwu nsogbu ahụike, yana ihe ize ndụ nke ọrịa obi. Ịnabata àgwà iri nri nke ọma ga-enyere aka ịchịkwa uricemia nke ọma ma belata ọrịa ndị metụtara ya.