Enwere ike ikpebi ntinye nke uric acid n'ime ọbara ma ọ bụ n'ime mmamịrị. N'ịgafe, ọ bụ isi ihe mgbaàmà nke gout, ịṅụbiga mmanya ókè ma ọ bụ ọdịda akụrụ.

Uric acid bụ a n'efu nke ahu. Kpọmkwem, ọ bụ ngwaahịa njedebe nkeexcrere ụmụ irighiri ihe a na-akpọ nucleic acid na purines.

Ọtụtụ mgbe, ihe ka ọtụtụ n'ime uric acid dị n'ahụ mmadụ na-agbaze n'ime ọbara wee banye na akụrụ maka mkpochapụ na mmamịrị. Mana n'ọnọdụ ụfọdụ, ahụ na-emepụta oke uric acid ma ọ bụ ọ naghị ewepụ oke ya. Ọnọdụ a nwere ike ịbụ ihe kpatara nsogbu dị iche iche.

Uric acid bụ ihe njedebe nke mmebi nke slurry, ọnụego ya dịgasị iche dabere na ọdịnaya purine dị n'ime ahụ. Ma ọ tụgharịrị na a na-ahụ purines karịsịa na nri. 

Ụfọdụ n'ime nri ndị nwere purines ndị a ga-ezere bụ:

• anchovies, azụ asa, mackerel, sardines, oporo, wdg;
• imeju, obi, ụbụrụ, akụrụ, achịcha ụtọ, wdg;
• peas, agwa akọrọ, wdg.

A naghị atụ aro ịṅụ mmanya na-aba n'anya, na karịsịa biya, mgbe ịchọrọ ibelata uric acid gị.

N'ụzọ megidere nke ahụ, n'ime nri ndị anabatara nwere obere purine, anyị nwere ike ikwu:

• tii, kọfị, ihe ọṅụṅụ dị nro;
• mkpụrụ osisi na akwụkwọ nri;
• akwa;
• achịcha na ọka;
• cheese na ihe ndị ọzọ n'ozuzu mmiri ara ehi

Kedu ihe kpatara uric acid ji nwalee?

Dọkịta ahụ na-enye iwu nnwale ọbara (nke a na-akpọ uricemia) na / ma ọ bụ ule uric acid nke urinary maka:

• chọpụta gout;
• chọpụta otú akụrụ na-arụ ọrụ nke ọma;
• enwere ike ịrịọ ya n'oge ime ime;
• ma ọ bụ na ndị buru ibu.

Rịba ama na nyocha nke ntinye nke uric acid na mmamịrị ga-emekwa ka o kwe omume ịghọta nke ọma mmalite nke uric acid dị elu n'ime ọbara.

N'ime ọbara, uru nkịtị nke uric acid dị n'etiti 35 na 70 mg / L.

A na-akpọ mkpokọta uric acid dị elu n'ọbara hyperuricemia na enwere ike bute ya site na mmụba nke uric acid n'ime ahụ ma ọ bụ mbelata mkpochapụ ya site na akụrụ. Yabụ, oke uric acid dị n'ọbara nwere ike ịbụ ihe ịrịba ama nke:

• gout (nke a bụ isi ihe kpatara mmụba nke uric acid n'ime ọbara);
• oke mbibi nke protein nke organism nke na-ewere ọnọdụ, dịka ọmụmaatụ, n'oge chemotherapy, leukemia ma ọ bụ ọbụna lymphoma;
• mmanya;
• mmega ahụ gabigara ókè;
• ọnụnọ nke akụrụ akụrụ;
• ọnwụ ngwa ngwa;
• ọrịa shuga;
• nri bara ụba na purine;
• preeclampsia n'oge ime ime;
• ma ọ bụ ọdịda akụrụ.

N'ụzọ megidere nke ahụ, ọ ga-ekwe omume na ọkwa uric acid ọbara dị ala karịa nke nkịtị, mana nke a bụ ọnọdụ dị ụkọ karịa ọnọdụ ebe ọ na-ejedebe elu.

Yabụ, ọkwa uric acid n'okpuru ụkpụrụ nkịtị nwere ike jikọta ya na:

• obere nri purine;
• Ọrịa Wilson (ọrịa mkpụrụ ndụ ihe nketa nke ọla kọpa na-ewulite n'ime ahụ);
• akụrụ (dị ka ọrịa Fanconi) ma ọ bụ mmebi imeju;
• ma ọ bụ ọbụna ikpughe na ogige ndị na-egbu egbu (ndu).

N'ime mmamịrị, uru uric acid nkịtị dị n'etiti 250 na 750 mg / awa 24.

Rịba ama na ụkpụrụ nkịtị nwere ike ịdịtụ iche dabere na ụlọ nyocha nke na -eme nyocha.

Na-emetụta 5 ruo 15% nke ndị bi na ya, ọ bụ ihe na-adịghị mma nke biochemical, nke sitere na mmụba nke uric acid na / ma ọ bụ mbelata mkpochapụ gbasara akụrụ. Ọ na-etolitekarị n'enweghị ihe mgbu, ya mere ọ bụghị mgbe niile ka a na-achọpụta ya ozugbo.

Enwere ike ịkọwa ọkwa uric acid dị elu site na:

Idiopathic ma ọ bụ hyperuricemia nke mbụ

Ha na-anọchi anya ọnụ ọgụgụ ka ukwuu nke ikpe. A na-ahụ ihe nketa nketa na 30% nke isiokwu, mana ha na-ejikọta ya na oke ibu, iribiga ihe ókè, ọbara mgbali elu, ịṅụbiga mmanya ókè, ọrịa shuga na hypertriglyceridemia.

Ọdịiche nke enzyme dị ụkọ

A na-ahụ ha karịsịa na ọrịa Von Gierke na ọrịa Lesch-Nyhan. Ndị a enzymatic abnormalities nwere akpan akpan nke na-ebute gout ọgụ nnọọ n'oge, ya bụ na mbụ 20 afọ nke ndụ.

Hyperuricemia nke abụọ nke ọrịa ma ọ bụ ọgwụgwọ ọgwụ.

Hyperuricemia nwere ike ịbụ n'ihi:

- enweghị mkpochapụ nke uric acid. Nke a bụ ikpe maka ọdịda akụrụ, kamakwa n'ihi ọgwụ ụfọdụ (diuretics, kamakwa laxatives na ụfọdụ ọgwụ mgbochi ụkwara nta).

- mmụba na mmebi nke nucleic acid. Anyị na-ahụ nke a na ọrịa ọbara (leukemia, hemopathies, hemolytic anaemia, psoriasis sara mbara), na nsonaazụ nke ụfọdụ chemotherapies cancer.

Nsonaazụ nke hyperuricemia

Hyperuricemia nwere ike ịkpata ụdị nsogbu abụọ:

• Gout na-ahụ maka mgbu nkwonkwo ụdị mkpali.

Mgbe microcrystals nke uric acid gbazere n'ime ọbara dị oke elu na ọnọdụ mpaghara dị mma (karịsịa acidity zuru oke nke ọkara), ha na-ebuli ma na-eduga na mbufụt mpaghara. Nke a na-emetụta nke ọma na nkwonkwo ụkwụ ukwu. Naanị 1 n'ime mmadụ 10 nwere uric acid dị ukwuu n'ọbara ha ga-enweta gout, yabụ ị ga-achọkwu ohere iji nweta ya.

• Urinary lithiasis.

Ha bụ n'ihi ọnụnọ nke otu nkume ma ọ bụ karịa na urinary tract na ọ bụ maka renal colic. Urolithiasis bụ ọrịa a na-ahụkarị ebe ọ bụ na 1 ruo 2% nke ndị bi na France na-emetụta.

Enwere ike ịme nyocha nke ọkwa nke otu acid n'ime ọbara na / ma ọ bụ n'ime mmamịrị:

• ule ọbara na-agụnye ihe nlele nke ọbara venous, na-emekarị na crease nke ikpere;
• A na-atụle ọkwa nke uric acid na mmamịrị karịa awa 24: iji mee nke a, ọ ga-ezuru mmamịrị n'ime akpa e nyere maka nzube a ma nye ndị ọrụ ahụike otu ụbọchị na otu abalị.

Rịba ama na ọ dị mma ka ị ghara iri ma ọ bụ ṅụọ ihe ọ bụla n'ime awa ndị bu ụzọ nyocha.

Enwere ọtụtụ ihe nwere ike imetụta ogo uric acid n'ime ọbara ma ọ bụ na mmamịrị. Ndị a gụnyere:

• nri (ogbenye ma ọ bụ elu na purines);
• ọgwụ (iji banye gout, aspirin, ma ọ bụ ọbụna diuretics);
• afọ, ụmụaka nwere ụkpụrụ dị ala;
• okike, na ụmụ nwanyị n'ozuzu nwere ọnụ ọgụgụ dị ala karịa ụmụ nwoke;
• ibu, ndị buru ibu nwere ọnụ ọgụgụ dị elu.

Ọgwụgwọ ọgwụ ma ọ bụrụ na hyperuremia bụ ihe mgbaàmà dị ka ndị a: 

• Nucleic acid synthesis ebelata, dị ka allopurinol. Ị ga-akpachara anya nke ukwuu n'ihi na enwere ọtụtụ mmekọrịta gị na ọgwụ ndị ọzọ.
• Ọgwụ na-egbochi renal uric acid reabsorption, dị ka benzbromaron.
• Ọgwụgwọ enzymatic nke na-ebutekarị nsogbu allergies.

Ihe ọ bụla mere, ọ bụ dọkịta ga-ekpebi ma a ga-agbaso ọgwụgwọ, na nke kachasị mma.