N'ime ma ndị nwoke ma ndị nwanyị, hormone luteinizing ma ọ bụ LH na-ekere òkè dị mkpa na ọmụmụ. Ọ bụ n'ezie akụkụ nke homonụ a maara dị ka gonadotropins, ndị na-eduzi glands ọmụmụ. Ya mere, ọgbaghara na nzuzo ya nwere ike bụrụ ihe mgbochi ịtụrụ ime.

luteinizing hormone ma ọ bụ LH (homonụ luteizing) a na-ezobe ya site na pituitary anterior. Ọ bụ akụkụ nke gonadotropins: ọ na-achịkwa, yana homonụ ndị ọzọ, glands mmekọahụ (gonads), na nke a, ovaries na ụmụ nwanyị na testes na ụmụ nwoke.

N'ime ụmụ nwanyị

Yana follicle stimulating hormone (FSH), LH na-arụ ọrụ dị mkpa na okirikiri ovarian. Ọ bụ kpọmkwem ịwa ahụ LH ga-akpalite ovulation n'oge usoro mmeghachi omume nke yinye:

• hypothalamus na-ezobe gnRHgonadotropin na-ewepụta homonụ) nke na-akpali pituitary gland;
• na nzaghachi, pituitary gland na-ezo FSH n'oge usoro nke mbụ nke okirikiri (site na ụbọchị mbụ nke nsọ nsọ ruo ovulation);
• n'okpuru mmetụta nke FSH, ụfọdụ ovarian follicles ga-amalite tozuo. Mkpụrụ ndụ ovarian nke dị n'akụkụ ebe ndị na-eto eto ovarian follicles ga-ezobewanye estrogen ọzọ;
• mmụba a na ọkwa estrogen n'ime ọbara na-arụ ọrụ na mgbagwoju anya hypothalamic-pituitary ma na-ebute nnukwu mwepụta nke LH;
• n'okpuru mmetụta nke mmụba LH a, esemokwu na follicle na-abawanye. Ọ na-agbaji ma na-achụpụ oocyte n'ime tube: nke a bụ ovulation, nke na-ewere ọnọdụ 24 ruo 36 awa mgbe LH gachara.

Mgbe ovulation gasịrị, LH na-aga n'ihu na-arụ ọrụ dị mkpa. N'okpuru mmetụta ya, ọkpụkpụ ovarian nke gbawara agbawa na-agbanwe ghọọ gland a na-akpọ corpus luteum nke na-emepụta estrogen na progesterone, hormones abụọ dị mkpa n'oge mmalite ime.

N'ime mmadụ

Dị ka ovaries, testes nọ n'okpuru njikwa FSH na LH. Nke ikpeazụ na-akpali mkpụrụ ndụ Leydig bụ ndị na-ahụ maka nzuzo nke testosterone. Ihe nzuzo LH na-adịtụ adịgide mgbe ntolitechara.

Enwere ike ịnye ọgwụ LH n'ọnọdụ dị iche iche:

N'ime ụmụ nwanyị

• na ọnụnọ nke ihe ịrịba ama nke precocious ma ọ bụ mbubreyo ntozu;
• n'ọnọdụ nsogbu ịhụ nsọ;
• n'ihe isi ike ịtụrụ ime: a na-eme nyocha nke hormonal n'usoro dị ka akụkụ nke nyocha nke infertility. Ọ gụnyere karịsịa mkpebi nke LH;
• ịchọpụta mmụba nke LH na mmamịrị na-emekwa ka o kwe omume ịchọpụta ụbọchị ovulation, ya mere, iji chọpụta windo ọmụmụ ya iji bulie ohere ịmụ nwa ya. Nke a bụ ụkpụrụ nke ule ovulation a na-ere na ụlọ ahịa ọgwụ;
• N'aka nke ọzọ, nyocha nke LH enweghị mmasị na nchọpụta nke menopause (HAS 2005) (1).

N'ime mmadụ

• na ọnụnọ nke ihe ịrịba ama nke precocious ma ọ bụ mbubreyo ntozu;
• n'ihe isi ike ịtụrụ ime: a na-eme nyocha nke hormonal n'usoro n'ime ụmụ nwoke. Ọ gụnyere karịsịa nyocha LH.

A na-enyocha LH site na nyocha ọbara dị mfe. N'ime ụmụ nwanyị, a na-eme ya na 2nd, 3rd ma ọ bụ 4th ụbọchị nke okirikiri na ụlọ nyocha nyocha, n'otu oge ahụ dị ka nyocha FSH na estradiol. N'ọnọdụ amenorrhea (enweghị oge), enwere ike iwere ihe nlele n'oge ọ bụla.

N'ihe gbasara nchoputa nke n'oge ma ọ bụ oge ntozu nwa agbọghọ ma ọ bụ nwa nwoke, a ga-ahọrọ usoro ọgwụgwọ mmamịrị. A na-ezobe gonadotropins FSH na LH n'ụdị na-adịghị mma n'oge oge ntolite ma kpochapụ ya na mmamịrị. Ya mere usoro onyocha mmamịrị na-eme ka o kwe omume ịchọpụta ọkwa nzuzo nke ọma karịa usoro onunu ogwu n'oge.

Na ụmụaka

Ọkwa dị elu nke FSH na LH nwere ike ịbụ ihe ịrịba ama nke ntozu ntozu.

N'ime ụmụ nwanyị

N'usoro, ọkwa LH dị elu na-eduga na ụkọ ovarian bụ isi (nsogbu na ovaries n'onwe ha na-akpata ụkọ gonadal) nke nwere ike ịbụ n'ihi:

• a congenital anomaly nke ovaries;
• chromosomal abnormality (ọrịa Turner karịsịa);
• ọgwụgwọ ma ọ bụ ịwa ahụ nke metụtara ọrụ ovarian (chemotherapy, radiotherapy);
• polycystic ovary syndrome (PCOS):
• ọrịa thyroid ma ọ bụ ọrịa adrenal;
• akpụ ovarian.

N'aka nke ọzọ, ọkwa LH dị ala na-eduga n'ọrịa ovarian nke abụọ nke mmalite dị elu (hypothalamus na pituitary) na-eduga na ụkọ nke mkpali gonadal. Otu n'ime ihe ndị na-akpatakarị bụ prolactin pituitary adenoma.

N'ime mmadụ

Ọkwa LH dị elu na-edochaghị anya na-eduzi nchoputa ahụ gaa n'ihu ọdịda testicular nke mbụ nke nwere ike ịbụ n'ihi:

• mmebi nke chromosomal;
• enweghi mmepe nke testes (testicular agenesis);
• trauma testicular;
• ọrịa;
• ọgwụgwọ (radiotherapy, chemotherapy);
• akpụ nke testicular;
• ọrịa autoimmune.

Ọkwa LH dị ala na-alaghachi na nsogbu nke mmalite dị elu, na pituitary na hypothalamus (ụbụrụ pituitary dịka ọmụmaatụ) na-eduga na ọdịda testicular nke abụọ.