Pepsinogen bụ enzyme na-eri nri nke afọ mmadụ na ọtụtụ ụdị anụmanụ ndị ọzọ zoro ezo. N'okpuru mmetụta nke gburugburu acidic nke afọ (pH gburugburu 2) ma ọ bụ pepsin n'onwe ya (nke a na-akpọ autoactivation), ọ na-agbanwe n'ime pepsin, onye ọrụ ya bụ tupu ịgbari protein. N'oge mgbari mgbaze, pepsin na-akụda protein n'ime agbụ polypeptides na oligopeptides dị mkpụmkpụ, nke na-emesịa na usoro mgbari nri na-ewere ọnọdụ na obere eriri afọ n'ime amino acid nke ọ bụla. N'okpuru mmetụta nke ihe mkpali ndị ọzọ, dị ka ọnụnọ nri na afọ ma ọ bụ acidification nke mucosa, ihe nzuzo ya na-abawanye.
Pepsin - eji ọgwụ eme ihe
A na-enweta ọgwụ ahụ site na mucosa gastric nke ezì, nwa ehi ma ọ bụ atụrụ. Mgbaze protein na-amalite na pH na-erughị 4; nnukwu mkpokọta hydrochloric acid anaghị arụ ọrụ Pepsi. Nkwadebe pepsyny ha na-abawanye agụụ, normalize pH nke ihe ọṅụṅụ gastric, ma na-eme ka mgbaze protein gastric.
Pepsin - egosi
Nkwadebe ndị nwere Pepsi tinye:
- n'ọrịa ndị nwere ụkọ pepsin endogenous,
- na enweghị agụụ,
- n'ime acid,
- ibelata secretion nke afọ,
- na gastritis na-adịghị ala ala,
- usoro ịgba ụka siri ike,
- na nnukwu gastritis na-adịghị ala ala,
- ọnọdụ mgbe gastrectomy gasịrị,
- nsogbu mgbari nri nke ọrịa imeju kpatara.
Mgbaàmà nke acidosis na acidity nwere ike ịdị ka ibe ya, ya mere nchọpụta dị mkpa. Ndị ọrịa na-emekarị mkpesa maka mgbaàmà na-adịghị mma ozugbo ha risịrị nri. Ndị a bụ: mmetụta nke oke ibu, ihe mgbu na afọ na gburugburu ya, mmetụta nke ịdị arọ na mpaghara afọ. Enwere ike inwe gas, nrekasi obi, flatulence, ọgbụgbọ, ma ọ bụ nsogbu na motility eriri afọ dị ka afọ ọsịsa ma ọ bụ afọ ntachi. Mgbe ụfọdụ afọ ọsịsa na afọ ntachi na-agbanwe. Afọ ọsịsa na-adịte aka na-agwụ ike maka ahụ ma na-eme ka onye ọrịa ghara ịda mbà. Ọrịa adịghị agbari nri nke ọma, anaghị anabata micro- na macroelements dị mkpa. Mgbe afọ na-emepụta ntakịrị ihe ọṅụṅụ mgbari nri, a pụghị ịgbari nri ahụ nke ọma. Efrata ndị siri ike mgbari ma ọ bụ na-eje ozi na-ekwesịghị ekwesị (esighi ya, atachaghị ya) ga-enweta naanị nhazi akụkụ, ọ dị mkpa ka ejiri ya mee ihe n'ụzọ zuru ezu ma jikọta ya. Nke a bụ ihe kpatara ya ụkọÍgwè na-esikarị ike inye mgbe ị bụ acid, ebe ọ bụ na a na-ahụkarị ya na anụ, nke na-esi ike mgbari. Enwekwara malabsorption nke magnesium, zinc (ya mere, inter alia, nsogbu na akpụkpọ ahụ, mbọ na ntutu) na calcium. Nnyocha na-egosi na ọnụọgụ hydrochloric acid ziri ezi dị mkpa maka nnabata nke vitamin B nke ọma, ọkachasị vitamin B12. A na-ejikọta ụkọ vitamin a na anaemia, adịghị ike n'ozuzu ma ọ bụ nsogbu nke usoro ụjọ ahụ, dịka ọmụmaatụ ịda mbà n'obi. Anyị nwekwara ike inwe nguzogide ọrịa ka njọ, n'ihi na vitamin C absorption dị njọ na ndị nwere obere afọ acid. N'ọnọdụ nke mgbaàmà ndị yiri ya, hụ dọkịta. Myirịta nke mgbaàmà nke hyperacidity gastric na acidity chọrọ nyocha nke ọma, na site na iru maka ọgwụ antacids na-ewu ewu, anyị nwekwara ike imerụ onwe anyị ahụ.
Pepsin - usoro onunu ogwu
A na-ekpebi usoro onunu ogwu n'otu n'otu dabere na nkwadebe, ihe ngosi maka ojiji ya na ọnọdụ onye ọrịa. Nkwadebe pepsyny ndinọ ozugbo tupu ma ọ bụ n'oge nri.
Nkwadebe na ahịa Polish nwere Pepsidị na ụlọ ahịa ọgwụ bụ:
- Citropepsin (mmiri),
- Bepepsin (mbadamba),
- Mixtura Pepsini, ngwakọta pepsin (mmiri mmiri) - dị na ndenye ọgwụ na ụlọ ahịa ọgwụ.
Pepsina ọ bụkwa ihe na-emekarị ihe mgbakwunye nri iji kwado mgbari nri ma ọ bụ ịlụso oke ibu ọgụ.