Fecal elastase bụ enzyme nke pancreas mepụtara nke na-ekere òkè na mgbari nri. Usoro onunu ogwu ya na-eme ka o kwe omume inyocha ịrụ ọrụ nke ọma nke pancreas metụtara mgbaze.

Pancreas bụ akụkụ ahụ mmadụ nwere ọrụ abụọ:

• ọrụ endocrine maka 10% nke sel: pancreas na-ezobe insulin na glucagon, homonụ abụọ na-ahụ maka ịhazi ọkwa shuga dị n'ọbara. Insulin na-ebelata shuga ọbara ebe glucagon na-abawanye ya. Hormone abụọ a na-enyere aka mee ka ọ̀tụ̀tụ̀ shuga dị n'ọbara guzozie n'ókè. Ọ bụrụ na enwere nsogbu na mmepụta insulin, anyị na-ekwu maka ọrịa shuga;
• ọrụ exocrine maka 90% nke sel: by sel acinar, pancreas na-ezobe enzymes pancreatic, protein nwere ọrụ pụrụ iche. Enzymes ndị a bụ akụkụ nke ihe ọṅụṅụ pancreatic ma dị mkpa maka mgbari nri kwesịrị ekwesị. Site na nhụsianya nke ọwa Wirsung na Santorini, ihe ọṅụṅụ pancreatic na-ahapụ pancreas ka ọ bịa gwakọta bile n'ime eriri afọ. N'ime tract digestive, enzymes ndị a na-ekere òkè na mgbaze nke abụba, protein na carbohydrates site n'imebi ha n'ọtụtụ ihe, na-eme ka ahụ dịkwuo mfe.

Fecal elastase bụ otu n'ime enzymes nke pancreas na-emepụta. A na-emepụta ya n'ụzọ kwụsiri ike na mgbe niile, nke na-eme ka ọ bụrụ ihe ngosi dị mma nke pancreatic. Ebumnuche nke nyocha fecal elastase bụ iji nyochaa ọrụ kwesịrị ekwesị nke ọrụ exocrine nke pancreas. Uru ntụaka bụ 200 micrograms kwa gram stool na ndị okenye ma ụmụaka (site na otu ọnwa). Uru a kwụsiri ike ma na-adịgasị iche site n'otu ụbọchị gaa na nke ọzọ n'otu onye ahụ ma e wezụga n'ihe gbasara afọ ọsịsa siri ike nke na-ebelata ọkwa fecal elastase. N'okwu a, a ga-emeghachi nyocha ahụ. Ọ bụ ule dị mfe ịme, nke na-enye ohere iji dochie anya ule ndị ọzọ siri ike dị ka ọmụmụ nke steatorrhea.

A na-eme nyocha a iji chọpụta ọrụ nke exocrine nke pancreas. Enwere ike ịme ya dịka ọmụmaatụ ma ọ bụrụ na a na-enyo enyo nke exocrine pancreatic insufficiency. Ọ nwekwara ike ịrịọ dọkịta ka ọ chọpụta ihe kpatara nsogbu afọ ọsịsa na-adịghị ala ala.

A na-eme mkpebi nke fecal elastase na ihe nlele stool. Onye ọrịa nwere ike ịnakọta ihe nlele ahụ n'ụlọ ya na ihe ndị ụlọ nyocha nyocha ahụike nyere. Ọ ga-ahapụ ngwa ngwa n'ime ụlọ nyocha maka nyocha. A ga-echekwa ihe nlele ahụ na 4 Celsius C (na friji). Ekwesịrị ịme nyocha ahụ n'ime awa 48 nke nchịkọta stool. Nke a bụ ule ELISA ụdị Sanwichi, nke akọwapụtara maka elastase mmadụ (elastase E1). Nnwale a nwere ikewapụ protein n'etiti ọgwụ mgbochi abụọ, nke ọ bụla na-amata otu n'ime protein ahụ, si otú a na-eme ka o kwe omume ịchọpụta na ịgụta ya.

Ọ bụrụ na agbakwunyere onye ọrịa ahụ na ọgwụgwọ nnọchi enzyme, nke a enweghị mmetụta na usoro ọgwụgwọ fecal elastase. N'aka nke ọzọ, ekwesịrị izere ụfọdụ ihe n'izu gara aga na n'ụbọchị nlele:

• nyocha redio digestive;
• nkwadebe maka colonoscopy;
• ndị laxatives;
• mgbakwasa eriri afọ ma ọ bụ ọgwụ mgbochi afọ ọsịsa. N'ezie, ihe ndị a nwere ike gbanwee flora intestinal ma ọ bụ mebie nsonaazụ nyocha ahụ.

N'otu aka ahụ, ọ bụ ihe amamihe dị na ya izere, ọ bụrụ na ọ ga-ekwe omume, nyocha a n'oge afọ ọsịsa siri ike. Ọ bụrụ na nke a agaghị ekwe omume, ekwesịrị igosi ya ka dọkịta ahụ nwee ike iburu ya n'uche mgbe ọ na-enyocha nsonaazụ ya.

Ọkwa elastase fecal dị ala (ma ewezuga afọ ọsịsa) na-egosi ezughị oke na ọrụ exocrine nke pancreas. Ntinye uche dị n'etiti 150 na 200 μg / g bụ ihe na-egosi ụkọ pancreatic exocrine na-agafeghị oke. Anyị na-ekwu maka nnukwu ụkọ pancreatic exocrine mgbe ọkwa fecal elastase na-erughị 15 µg / g.

Site n'ebe ahụ, dọkịta ga-achọ ime nyocha ọzọ, nyocha na onyonyo iji chọpụta ihe kpatara ụkọ a. Enwere ọtụtụ ohere:

• pancreatitis na-adịghị ala ala;
• nnukwu pancreatitis;
• ọrịa cystic fibrosis;
• ọrịa shuga;
• ọrịa celiac;
• Ọrịa Crohn;
• Zollinger-Ellison ọrịa;
• ịwa ahụ tract digestive elu;
• wdg