Le fibrinogen bụ a protein ọbara nke na -ekere òkè na ya nsị. Ọ na -esonye na ọzụzụ nke nkedo ọbara ma na -agbanwekwa ọrụ nke platelet ọbara na cell nke arịa. N'okpuru ọrụ nke protein ọzọ, ahụ thrombin, ọ na -atụgharị n'ime fibrin

Ọ bụ sel imeju na -emepụta ya. Ogo ya n'ọbara na -adịkarị site na 2 ruo 4 g / l. Agbanyeghị, njikọ nke a protein nwere ike ịbawanye n'ihi nrụgide, n'oge ime ime, ma ọ bụ gbanye ọgwụ ụfọdụ ma ọ bụ homonụ nke uto. Mmụba nke ọkwa fibrinogen n'ime ọbara na -egosikwa ọnọdụ mkpali.

A na -egosi nnwale fibrinogen iji nyocha maka ọrịa ọgbụgba ọbara (dịka ọmụmaatụ ma ọ bụrụ na ọbara ọgbụgba akọwaghị ma ọ bụ ” ọrịa defibrination », Kwekọrọ n'ihe na -adịghị mma coagulation).

Enwere ntụpọ ọmụmụ atọ na ọkwa fibrinogen:

• THEafibrinogenemia, nke bụ enweghị fibrinogen zuru oke. Ọrịa a na -adịghị ahụkebe na -ebute ọbara ọgbụgba siri ike nke na -eme site na ọmụmụ
• THEhypofibrinogenemia, nke kwekọrọ na mbelata ọkwa fibrinogen n'ime ọbara (nke a bụ ntụpọ na nzuzo, ọtụtụ mgbe)
• La ọrịa dysfibrinogenemia, nke bụ ihe na -adịghị ahụkebe nke protein.

Nnwale fibrinogen ọbara nwekwara ike ịba uru n'ọnọdụ ndị a:

• ọrịa mkpali
• imeju imeju (na -eduga n'ịbelata ọkwa fibrinogen)
• iji nyochaa mmetụta ọgwụgwọ a na-akpọ “fibrinolytic”, nke ezubere igbari akwakọba ọbara ma ọ bụrụ thrombosis.

Ọdịdị nke fibrinogen a na -eme na nlele ọbara venous (nnwale ọbara), n'ime ụlọ nyocha nyocha ahụike. Ọnụọgụ ọgwụ bụ ihe a na -eme kwa ụbọchị, a na -enwetakwa nsonaazụ n'ime ụbọchị.

Dọkịta bụ naanị onye nwere ike ịkọwa nsonaazụ nyocha ahụ.

Ọtụtụ mgbe, fibrinogen gafere (hyperfibrinogenemia) Enwere ike ịhụ ya ma ọ bụrụ na mbufụt, ọ bụrụ na ụfọdụ ọrịa na -efe efe (oyi baa, wdg), ma ọ bụrụ na ahụ ọkụ rheumatic ma ọ bụ ọrịa autoimmune (lupus), mgbe myocardial infarction, wdg.

N'aka nke ọzọ, hypofibrinogenemia (mbelata ọkwa fibrinogen) nwere ike igosipụta ọrịa mkpụrụ ndụ ihe nketa, ọdịda imeju siri ike (ịba ọcha n'anya, cirrhosis), nsogbu coagulation (gbasasịa coagulation intravascular ma ọ bụ syndrome defibrination) ma ọ bụ “fibrinolysis”, dịka ọmụmaatụ n'ihi ọrịa kansa.