Le cortisol bụ a homonụ steroid mepụtara site na cholesterol na secreted site glands n'elu akụrụ (the adrenal cortex). Ihe nzuzo ya dabere na hormone ọzọ, ACTH nke pituitary gland na-emepụta na ụbụrụ (ACTH maka adrenocorticotropin).

Cortisol na-arụ ọtụtụ ọrụ na ahụ, gụnyere:

• Metabolism nke carbohydrates, lipids na protein: ọ na-enyere aka ịhazi shuga ọbara site na ịba ụba glucose site na imeju (gluconeogenesis), mana na-akpali ntọhapụ nke lipids na protein n'ọtụtụ anụ ahụ.

• Nwere mgbochi mkpali mmeghachi omume

• Ijikwa ọbara mgbali elu

• Ka ọkpụkpụ na-eto eto

• Nzaghachi nrụgide: A na-akpọkarị Cortisol dị ka hormone nchekasị. Ọrụ ya bụ inyere ahụ aka ịnagide, site n'ịchịkọta ike dị mkpa iji na-azụ anụ ahụ, ụbụrụ kamakwa obi.

Rịba ama na ọkwa nke cortisol dịgasị iche dabere na oge ehihie na abalị: ọ kachasị elu n'ụtụtụ ma na-ebelata ụbọchị dum iji ruo ọkwa kachasị ala na mgbede.

Dọkịta nyere iwu ka a nwalee ọkwa nke cortisol dị n'ọbara iji lelee maka mmebi nke gland adrenal ma ọ bụ gland pituitary. A na-atụkarị Cortisol na ACTH n'otu oge.

Nyocha ahụ nwere a nyocha ọbaraNke a bụ mgbe ọkwa cortisol dị elu ma kwụsie ike n'ụtụtụ n'etiti elekere asaa na elekere 7 nke ụtụtụ. Ndị ọrụ ahụike na-ahụ maka nyocha ahụ ga-enweta ọbara venous, na-abụkarị site n'ogige nke ikpere.

Ebe ọ bụ na ọkwa cortisol na-agbanwe n'ime ụbọchị dum, enwere ike ịme ule ahụ ọtụtụ oge iji nweta nkọwa ziri ezi karịa nkezi mmepụta cortisol.

Enwere ike tụọ ọkwa nke cortisol na mmamịrị (nleba anya nke cortisol na-enweghị urinary, karịsịa bara uru maka ịchọpụta hypersecretion nke cortisol). Iji mee nke a, a ga-anakọta mmamịrị n'ime akpa enyere maka nke a n'ime awa 24.

Anyị ga-akọwara gị usoro a, nke na-agụnye ịnakọta mmamịrị niile maka ụbọchị (site na ịchekwa ya n'ebe dị jụụ).

Tupu ịme ule (ọbara ma ọ bụ mmamịrị), a na-atụ aro ka ị zere ọnọdụ nrụgide ọ bụla ma ọ bụ imega ahụ. Dọkịta ahụ nwekwara ike ịrịọ ka ịkwụsị ọgwụgwọ ụfọdụ nwere ike igbochi usoro onunu ogwu nke cortisol (estrogen, androgens, wdg).

N'ime ọbara, uru cortisol kwesịrị ịdị n'etiti 7 am na 9 am bụ n'etiti 5 na 23 μg / dl (micrograms kwa deciliter).

N'ime mmamịrị, ọkwa nke cortisol a na-enwetakarị dị n'etiti 10 na 100 μg / 24h (microgram kwa awa 24).

Ọkwa cortisol dị elu nwere ike ịbụ akara nke:

• Ọrịa Cushing (ọbara mgbali elu, oke ibu, hyperglycemia, wdg).

• a benign ma ọ bụ njọ adrenal gland tumor

• nnukwu ọrịa

• ọrịa strok, myocardial infarction

• ma ọ bụ cirrhosis nke imeju, ma ọ bụ mmanya na-adịghị ala ala

N'ụzọ megidere nke ahụ, ọkwa dị ala nke cortisol nwere ike ịbụ otu ihe:

• adrenal ezughi oke

• ọrịa Addison

• arụ ọrụ na-adịghị mma nke pituitary ma ọ bụ hypothalamus

• ma ọ bụ bụrụ n'ihi ọgwụgwọ corticosteroid ogologo oge

Naanị dọkịta ga-enwe ike ịkọwa nsonaazụ ya wee nye gị nyocha (nlele ndị ọzọ na-adị mkpa mgbe ụfọdụ).