Agranulocytosis bụ ihe na-adịghị mma nke ọbara na-apụta site na mwepu nke subclass nke leukocytes: neutrophilic granulocytes. N'iburu mkpa ha dị na sistemu ahụ ji alụso ọrịa ọgụ, ọpụpụ ha chọrọ ọgwụgwọ ahụike ngwa ngwa.

Agranulocytosis bụ okwu ahụike eji ezo aka n'ọgba aghara ọbara. Ọ dabara na ihe fọrọ nke nta ka ọ bụrụ mkpokọta granulocytes neutrophil ọbara, nke a na-akpọbu neutrophils ọbara.

Akụkụ ọbara ndị a bụ subclass nke leukocytes (sel ọbara ọcha), mkpụrụ ndụ ọbara na-etinye aka na sistemu ahụ ji alụso ọrịa ọgụ. Nke a subclass na-anọchi anya ọtụtụ leukocytes dị na ọbara. N'ime ọbara, neutrophil granulocytes na-arụ ọrụ dị oke mkpa n'ihi na ọ bụ ha na-ahụ maka nchebe megide ndị mba ọzọ na sel ndị nwere ọrịa. Ha na-enwe ike phagocyte ihe ndị a, ya bụ na ha na-amịkọrọ ha iji bibie ha.

Agranulocytosis bụ ọrịa na-adịghị ala ala nke nwere ike ịmata ya na a hemogram, nke a na-akpọkwa Ọbara Count and Formula (NFS). Nnwale a na-enye ọtụtụ ozi gbasara mkpụrụ ndụ ọbara. Ọnụ ọgụgụ ọbara na-eme ka o kwe omume karịsịa ịkọwapụta ihe dị iche iche nke ọbara, nke neutrophil granulocytes bụ akụkụ.

N'oge'neutrophil analysis, a na-ahụ ihe na-adịghị mma mgbe ntinye nke mkpụrụ ndụ ndị a na-erughị 1700 / mm3, ma ọ bụ 1,7 g / L n'ime ọbara. Ọ bụrụ na ọkwa nke neutrophilic granulocytes dị ala, anyị na-ekwu maka a neutropenia.

Agranulocytosis bụ ụdị neutropenia siri ike. A na-eji ọkwa dị ala nke neutrophilic granulocytes mara ya, ihe na-erughị 500 / mm3, ma ọ bụ 0,5 g / L.

N'ọtụtụ ọnọdụ, agranulocytosis bụ ihe na-adịghị mma nke ọbara nke na-eme mgbe ọ nwụsịrị ọgwụgwọ ụfọdụ. Dabere na mmalite na njirimara nke anomaly, enwere ụdị ọgwụ abụọ agranulocytosis:

• nnukwu agranulocytosis kpatara ọgwụ ọjọọ, mmepe nke bụ n'ihi nhọrọ toxicity nke ọgwụ, nke na-emetụta nanị eriri granulocyte;
• agranulocytosis nke ọgwụ na-akpata na ọnọdụ nke anaemia aplastic, mmepe nke ya bụ n'ihi nsogbu nke ọkpụkpụ ọkpụkpụ, bụ nke a na-eji nbibi nke ọtụtụ ahịrị sel ọbara.

N'ihe gbasara anaemia aplastic, ọ ga-ekwe omume ịmata ọdịiche dị iche iche nke agranulocytosis. N'ezie, ọrịa ọbara a nke e ji nkwụsịtụ na mmepụta nke mkpụrụ ndụ ọbara na ụmị ọkpụkpụ nwere ike ịmalite ọtụtụ mmalite. Enwere ike ịtụle anaemia aplastic dị ka:

• post-chemotherapy aplastic anaemia mgbe ị na-eso ọgwụgwọ chemotherapy;
• aplastic anaemia na mberede mgbe ọgwụ ụfọdụ kpatara ya.

Ọ bụ ezie na agranulocytosis nke ọgwụ na-akpata na-anọchite anya n'etiti 64 na 83% nke ikpe, ihe ndị a na-adịghị mma nwere ike inwe ihe ndị ọzọ. Site na nje bacteria, nje ma ọ bụ nje nje, ọrịa na-efe efe na ọkwa dị elu nwere ike ime ka mbelata nke granulocytes neutrophilic.

Nyere ọrụ nke neutrophilic granuclocytes n'ime usoro ahụ ji alụso ọrịa ọgụ, agranulocytosis na-ekpughere akụkụ ahụ n'ihe ize ndụ dị ukwuu nke ibute ọrịa. Neutrophils adịkwaghị ọtụtụ nke na-emegide mmepe nke ụfọdụ pathogens, nke nwere ike ibute a septicemia, ma ọ bụ sepsis, ọrịa a na-ahụkarị ma ọ bụ mbufụt nke ahụ.

Mgbaàmà nke agranulocytosis bụ nke ọrịa. Ọ nwere ike igosipụta onwe ya site na ihe ịrịba ama na-efe efe na mpaghara dị iche iche nke ahụ gụnyere sistemu digestive, akụkụ ENT, usoro akpa ume ma ọ bụ ọbụna akpụkpọ ahụ.

Agranulocytosis siri ike nke ọgwụ kpatara na-apụta na mberede ma na-egosipụta ya site na ntiwapụ nke nnukwu ahụ ọkụ (karịa 38,5 Celsius C) na oyi na-atụ. Na ụmị ọkpụkpụ aplasia, mmepe nke agranulocytosis nwere ike ịdị nwayọọ nwayọọ.

Agranulocytosis bụ ihe na-adịghị mma nke ọbara nke kwesịrị ka a gwọọ ya ngwa ngwa iji zere nsogbu. Ọ bụ ezie na ọgwụgwọ nwere ike ịdịgasị iche dabere na mmalite nke agranulocytosis, njikwa ya na-adaberekarị na:

• ikewapụ n'ụlọ ọgwụ iji chebe onye ọrịa;
• mmalite nke ọgwụ nje iji gwọọ ọrịa;
• ojiji nke granulocyte uto ihe na-akpali mmepụta nke neutrophilic granulocytes.